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Catalysis with In Situ-Generated (Hypo)iodite Ions for Oxidative Coupling Reactions

Authors

  • Dr. Muhammet Uyanik,

    1. Graduate School of Engineering Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3222
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  • Prof. Dr. Kazuaki Ishihara

    Corresponding author
    1. Graduate School of Engineering Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3222
    2. Japan Science and Technology Agency (JST), CREST, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan)
    • Graduate School of Engineering Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3222

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Abstract

This Concept highlights the discovery and development of oxidative coupling reactions catalyzed by the hypoiodite (I[BOND]O) or iodite (O[DOUBLE BOND]I[BOND]O) ion, which are generated in situ from iodide (I) ion with hydrogen peroxide or tert-butyl hydroperoxide as an environmentally benign oxidant. The most important features of these catalytic systems are 1) metal-free oxidation, 2) milder reaction conditions, 3) high chemoselectivity (they tolerate a wide range of various functional groups), 4) operational simplicity, and 5) water or tert-butyl alcohol as the only byproduct derived from the co-oxidant used.

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