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Keywords:

  • domino reactions;
  • enantioselectivity;
  • molecular diversity;
  • organocatalysis;
  • synthetic methods
Thumbnail image of graphical abstract

Pushing the dominos after 100 years: Almost a century has elapsed since the pioneer one-pot preparation of a racemic functionalized bicyclo[3.2.1]octane nucleus in 1903, and their first metal-catalyzed direct enantioselective synthesis from achiral precursors in 1999. Both metallic and organic catalytic domino transformations are pivotal developments in the direct construction of functionalized bicyclo[3.2.1]octanes from simple achiral precursors.