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Single-Step Metallocatalyzed and Organocatalyzed Enantioselective Construction of Bicyclo[3.2.1]octanes
Article first published online: 6 DEC 2011
DOI: 10.1002/cctc.201100357
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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How to Cite
Presset, M., Coquerel, Y. and Rodriguez, J. (2012), Single-Step Metallocatalyzed and Organocatalyzed Enantioselective Construction of Bicyclo[3.2.1]octanes. ChemCatChem, 4: 172–174. doi: 10.1002/cctc.201100357
Publication History
- Issue published online: 27 JAN 2012
- Article first published online: 6 DEC 2011
- Manuscript Received: 11 OCT 2011
Funded by
- French Research Ministry
- CNRS
- Abstract
- Article
- References
- Cited By
Keywords:
- domino reactions;
- enantioselectivity;
- molecular diversity;
- organocatalysis;
- synthetic methods
Pushing the dominos after 100 years: Almost a century has elapsed since the pioneer one-pot preparation of a racemic functionalized bicyclo[3.2.1]octane nucleus in 1903, and their first metal-catalyzed direct enantioselective synthesis from achiral precursors in 1999. Both metallic and organic catalytic domino transformations are pivotal developments in the direct construction of functionalized bicyclo[3.2.1]octanes from simple achiral precursors.