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Single-Step Metallocatalyzed and Organocatalyzed Enantioselective Construction of Bicyclo[3.2.1]octanes

Authors

  • Dr. Marc Presset,

    1. Aix-Marseille Université, UMR CNRS 6263 iSm2, Centre Saint Jérôme, service 531, 13397 Marseille Cedex 20 (France), Fax: (+33) 491-289-187
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  • Dr. Yoann Coquerel,

    Corresponding author
    1. Aix-Marseille Université, UMR CNRS 6263 iSm2, Centre Saint Jérôme, service 531, 13397 Marseille Cedex 20 (France), Fax: (+33) 491-289-187
    • Aix-Marseille Université, UMR CNRS 6263 iSm2, Centre Saint Jérôme, service 531, 13397 Marseille Cedex 20 (France), Fax: (+33) 491-289-187

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  • Prof. Dr. Jean Rodriguez

    Corresponding author
    1. Aix-Marseille Université, UMR CNRS 6263 iSm2, Centre Saint Jérôme, service 531, 13397 Marseille Cedex 20 (France), Fax: (+33) 491-289-187
    • Aix-Marseille Université, UMR CNRS 6263 iSm2, Centre Saint Jérôme, service 531, 13397 Marseille Cedex 20 (France), Fax: (+33) 491-289-187

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Abstract

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Pushing the dominos after 100 years: Almost a century has elapsed since the pioneer one-pot preparation of a racemic functionalized bicyclo[3.2.1]octane nucleus in 1903, and their first metal-catalyzed direct enantioselective synthesis from achiral precursors in 1999. Both metallic and organic catalytic domino transformations are pivotal developments in the direct construction of functionalized bicyclo[3.2.1]octanes from simple achiral precursors.

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