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Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β-Functionalization of Aldehydes
Article first published online: 14 MAR 2012
DOI: 10.1002/cctc.201100488
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Xiao, J. (2012), Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β-Functionalization of Aldehydes. ChemCatChem, 4: 612–615. doi: 10.1002/cctc.201100488
Publication History
- Issue published online: 24 APR 2012
- Article first published online: 14 MAR 2012
- Manuscript Received: 19 DEC 2011
Funded by
- National Natural Science Foundation of China. Grant Number: 21102142
- Dalian Institute of Chemical Physics
- Chinese Academy of Sciences
- Abstract
- Article
- References
- Cited By
Keywords:
- aldehydes;
- enamine;
- enantioselective;
- organocatalysis;
- oxidation
Jekyll and aldeHyde: The oxidation of enamines to iminium species by 2-iodoxybenzoic acid (IBX) or 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) catalyzed by a chiral secondary amine catalyst enabled the unprecedented enantioselective β-functionalization of aldehydes with various nucleophiles in high stereoselectivity.