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Oxidative Enamine Catalysis: Direct Catalytic Enantioselective β-Functionalization of Aldehydes

Authors

  • Prof. Jian Xiao

    Corresponding author
    1. Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023 (P.R. China)
    • Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023 (P.R. China)
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Abstract

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Jekyll and aldeHyde: The oxidation of enamines to iminium species by 2-iodoxybenzoic acid (IBX) or 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) catalyzed by a chiral secondary amine catalyst enabled the unprecedented enantioselective β-functionalization of aldehydes with various nucleophiles in high stereoselectivity.

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