Pull the trigger! The use of (Z)-β,β-bromo-nitroalkenes under enamine catalysis provides the 1,4-Michael adduct intermediate, which upon treatment with the desired amine (R3NH2) triggers the domino reaction to provide the final 3,4-disubstituted pyrrole derivatives.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.