Get access
Advertisement

Modular Three-Component Organocatalytic Synthesis of 3,4-Disubstituted Pyrroles by a One-Pot Domino Reaction

Authors

  • Cecilia Martín-Santos,

    1. Department of Inorganic Chemistry (Módulo-7), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    Search for more papers by this author
  • Carlos Jarava-Barrera,

    1. Department of Inorganic Chemistry (Módulo-7), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    Search for more papers by this author
  • Dr. Alejandro Parra,

    1. Department of Organic Chemistry (Módulo-1), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain), Fax: (+34) 91497466
    Search for more papers by this author
  • Francisco Esteban,

    1. Department of Inorganic Chemistry (Módulo-7), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    Search for more papers by this author
  • Prof. Carmen Navarro-Ranninger,

    1. Department of Inorganic Chemistry (Módulo-7), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain)
    Search for more papers by this author
  • Dr. José Alemán

    Corresponding author
    1. Department of Organic Chemistry (Módulo-1), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain), Fax: (+34) 91497466
    • Department of Organic Chemistry (Módulo-1), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid (Spain), Fax: (+34) 91497466
    Search for more papers by this author

Abstract

original image

Pull the trigger! The use of (Z)-β,β-bromo-nitroalkenes under enamine catalysis provides the 1,4-Michael adduct intermediate, which upon treatment with the desired amine (R3NH2) triggers the domino reaction to provide the final 3,4-disubstituted pyrrole derivatives.

Get access to the full text of this article

Ancillary