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Advances and Applications in Organocatalytic Asymmetric aza-Michael Addition

Authors

  • Prof. Dr. Jun Wang,

    1. Department of Chemistry, South University of Science and Technology of China, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong (P.R. China), Fax: (+86) 755-86245672
    2. School of Chinese Medicine, The Hong Kong Baptist University, Kowloon Tong, Hong Kong (P.R. China)
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  • Prof. Dr. Pengfei Li,

    Corresponding author
    1. Department of Chemistry, South University of Science and Technology of China, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong (P.R. China), Fax: (+86) 755-86245672
    • Department of Chemistry, South University of Science and Technology of China, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong (P.R. China), Fax: (+86) 755-86245672
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  • Pui Ying Choy,

    1. State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (P.R. China), Fax: (+852) 2364-9932
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  • Prof. Dr. Albert S. C. Chan,

    Corresponding author
    1. Presidential Suite and Institute of Creativity, The Hong Kong Baptist University, Kowloon Tong, Hong Kong (PR. China)
    • Presidential Suite and Institute of Creativity, The Hong Kong Baptist University, Kowloon Tong, Hong Kong (PR. China)
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  • Prof. Dr. Fuk Yee Kwong

    Corresponding author
    1. State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (P.R. China), Fax: (+852) 2364-9932
    • State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong (P.R. China), Fax: (+852) 2364-9932
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Abstract

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Go forth and make bonds: The aza-Michael addition is an excellent way of forming C[BOND]N bonds and is of tremendous significance in asymmetric synthesis. Recently, impressive progress has been achieved by employing new nitrogen nucleophiles, suitable acceptors, and more efficient catalyst systems for this important transformation. This review surveys the advances among intermolecular- and intramolecular aza-Michael addition and domino reactions involved aza-Michael addition developed between 2010 and early 2012.

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