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Keywords:

  • azoles;
  • enantioselective;
  • guanidine;
  • Morita–Baylis–Hillman reaction;
  • organocatalysis
Thumbnail image of graphical abstract

A catalyst is more than ones and zeros: The efficient catalysis for the Morita–Baylis–Hillman reaction of aromatic aldehydes with cyclic enones was demonstrated using a binary catalytic system consisting of a guanidine derivative and an azole derivative. The present binary system is well embedded into the catalytic cycles to stabilize the anionic intermediates through the hydrogen-bonding interaction with the guanidinium ion.