Ruthenium-Catalyzed Carbonylation of ortho C[BOND]H Bonds in Arylacetamides: C[BOND]H Bond Activation Utilizing a Bidentate-Chelation System

Authors

  • Kaname Shibata,

    1. Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7396
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  • Nao Hasegawa,

    1. Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7396
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  • Dr. Yoshiya Fukumoto,

    1. Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7396
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  • Prof. Naoto Chatani

    Corresponding author
    1. Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7396
    • Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871 (Japan), Fax: (+81) 6-6879-7396
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Abstract

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Karma karma karma chelation: Direct carbonylation of C[BOND]H bonds in arylacetamides was achieved using a bidentate-chelation system. The use of 2-pyridynylmethyl amino moiety is essential for the reaction to proceed. For achieving an efficient reaction, the presence of both ethylene (for a hydrogen acceptor) and H2O (probably for an efficient generation of catalytic active species) are required.

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