Copper-Catalyzed Direct Synthesis of Benzamides from Alcohols and Amines

Authors

  • Dr. Xavier Bantreil,

    Corresponding author
    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM I-UM II, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5 (France)
    • Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM I-UM II, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5 (France)
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  • Clément Fleith,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM I-UM II, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5 (France)
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  • Prof. Dr. Jean Martinez,

    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM I-UM II, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5 (France)
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  • Dr. Frédéric Lamaty

    Corresponding author
    1. Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM I-UM II, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5 (France)
    • Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-UM I-UM II, Université Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5 (France)
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Abstract

original image

Ready, steady, copper! The efficient copper-catalyzed formation of amides, from benzylic alcohols and hydrochloride salts of primary- and secondary amines, uses cheap and readily available copper oxide, as well as tert-butylhydroperoxide (TBHP) as an oxidant.

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