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Phosphine Organocatalysis in the Synthesis of Natural Products and Bioactive Compounds
Article first published online: 12 OCT 2012
DOI: 10.1002/cctc.201200442
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Gomez, C., Betzer, J.-F., Voituriez, A. and Marinetti, A. (2013), Phosphine Organocatalysis in the Synthesis of Natural Products and Bioactive Compounds. ChemCatChem, 5: 1055–1065. doi: 10.1002/cctc.201200442
Publication History
- Issue published online: 26 APR 2013
- Article first published online: 12 OCT 2012
- Manuscript Revised: 23 JUL 2012
- Manuscript Received: 4 JUL 2012
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Keywords:
- bioactive compounds;
- cyclizations;
- natural products;
- organocatalysis;
- phosphine;
- totalsynthesis
Abstract
During the last few years, synthetic methods based on phosphine organocatalysis have experienced extremely fast developments. This short overview is intended to demonstrate that these methods can afford suitable tools for the constitution of either focused or diversity-oriented-synthesis (DOS) inspired libraries of small molecules for biological screening. It also reports selected examples where these organocatalytic methods have been used conveniently as key steps in the formal or total synthesis of complex natural products. Especially, synthetic applications of the inter- and intramolecular cyclizations of unsaturated substrates have been considered in this review.