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Keywords:

  • biocatalysis;
  • biphasic catalysis;
  • oxygen;
  • photochemistry;
  • sulfoxidation

Abstract

Biocatalysis, which occurs mostly in aqueous reaction media, is generally incompatible with the hydrophobic nature of many reactants. This may be overcome by using the two-liquid-phase system (2 LPS) approach. We demonstrate the beneficial application of the 2 LPS approach for the photobiocatalytic oxyfunctionalization of thioanisole. Compared to aqueous reaction conditions, the 2 LPS approach not only allowed for higher substrate loadings (without the use of additional solvents) but also increased the productivity and robustness of the overall reaction.