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Direct Amidation of Aldehydes with Primary Amines under Mild Conditions Catalyzed by Diolefin-Amine–RhI Complexes

Authors

  • Rafael E. Rodríguez-Lugo,

    1. Department of Chemistry and Applied Biosciences, ETH-Hönggerberg, 8093 Zürich (Switzerland), Fax: (+41) 44-633-1032
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  • Dr. Mónica Trincado,

    Corresponding author
    1. Department of Chemistry and Applied Biosciences, ETH-Hönggerberg, 8093 Zürich (Switzerland), Fax: (+41) 44-633-1032
    • Department of Chemistry and Applied Biosciences, ETH-Hönggerberg, 8093 Zürich (Switzerland), Fax: (+41) 44-633-1032
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  • Prof. Dr. Hansjörg Grützmacher

    Corresponding author
    1. Department of Chemistry and Applied Biosciences, ETH-Hönggerberg, 8093 Zürich (Switzerland), Fax: (+41) 44-633-1032
    • Department of Chemistry and Applied Biosciences, ETH-Hönggerberg, 8093 Zürich (Switzerland), Fax: (+41) 44-633-1032
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Abstract

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Rhodium teaches toleration: The diolefin-amine–RhI complex [Rh(OTf)(trop2NH)(PPh3)] (see scheme) is an effective pre-catalyst for the amidation of a wide range of aldehydes with primary amines. The corresponding amides are obtained in good-to-excellent yields under very mild reactions conditions and a variety of functional groups are tolerated.

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