Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines



The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag[BOND]Pd alloy nanoparticles supported on carbon. Ag[BOND]Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.