The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with AgPd alloy nanoparticles supported on carbon. AgPd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields α-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedländer synthesis to give polysubstituted quinolines in moderate to good yields.
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