Clean, Convenient, High-yield Access to Second-generation Ru Metathesis Catalysts from Commercially Available Precursors

Authors

  • Dr. Bianca J. van Lierop,

    1. Centre for Catalysis Research & Innovation, and Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5 (Canada)
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  • Amy M. Reckling,

    1. Centre for Catalysis Research & Innovation, and Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5 (Canada)
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  • Justin A. M. Lummiss,

    1. Centre for Catalysis Research & Innovation, and Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5 (Canada)
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  • Prof. Deryn E. Fogg

    Corresponding author
    1. Centre for Catalysis Research & Innovation, and Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5 (Canada)
    • Centre for Catalysis Research & Innovation, and Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5 (Canada)
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Abstract

Expedient routes are described to the three dominant ruthenium catalysts currently used for olefin metathesis: the second-generation Grubbs, Hoveyda, and indenylidene catalysts. Ligand exchange of the first-generation PCy3 complexes with isolated free H2IMes, followed by treatment with a cation- exchange resin to remove the liberated phosphine, affords the clean targets in ≥95 % isolated yield from commercially available precursors, with no workup other than filtration and evaporation.

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