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Keywords:

  • C[BOND]H bond activation;
  • chemoselectivity;
  • amides;
  • cross-coupling;
  • palladium
Thumbnail image of graphical abstract

Under an oxygen umbrella: The Pd-catalyzed aerobic oxidative coupling of benzene derivatives with acrylates provides an efficient and atom-economical route to cinnamamides (see scheme). Readily available starting materials are used and molecular oxygen serves as the sole oxidant. By using this system, the chemoselective oxidative coupling reaction can provide either monoarylation or diarylation products simply by changing the molar ratio of Pd/acacH.