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  • Open Access

Biocatalytic Methods for C[BOND]C Bond Formation

Authors

  • Dr. Kateryna Fesko,

    1. ACIB GmbH (Austrian Centre of Industrial Biotechnology) c/o Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz (Austria), Fax: (+43) 316-873-1032410
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  • Dr. Mandana Gruber-Khadjawi

    Corresponding author
    1. ACIB GmbH (Austrian Centre of Industrial Biotechnology) c/o Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz (Austria), Fax: (+43) 316-873-1032410
    • ACIB GmbH (Austrian Centre of Industrial Biotechnology) c/o Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz (Austria), Fax: (+43) 316-873-1032410
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Abstract

Carbon-carbon bond formation is among the most challenging transformations in the organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest. The enzymes for stereoselective C[BOND]C bond formations have been investigated very intensively during the last two decades. New recombinant DNA technologies have paved the way for improved catalysts and broaden the application scope of the already known enzymes and reactions. On the other side new discoveries have brought more enzyme players in the arena of C[BOND]C bond formation reactions. Novel enzymatic C[BOND]C bond formation reactions have been applied, implying the most important benefit of biocatalysis, namely the high selectivity.

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