Single Operation Stereoselective Synthesis of Aerangis Lactones: Combining Continuous Flow Hydrogenation and Biocatalysts in a Chemoenzymatic Sequence



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Smart catalysis cuts it short: Natural (S,S)-Aerangis lactone and its epimer are synthesized with excellent optical purity by using in-line hyphenation of continuous flow reactors and batch biotransformations. Optimization of the reaction steps and engineering of the reactor interfaces leads to a simple and efficient setup, which demonstrates how multistep syntheses can be streamlined into a single-operation protocol.