N,O problem: An asymmetric catalytic one-pot N,O- and O,O-acetalization cascade is presented. This strategy is based on catalytic asymmetric conjugate addition and subsequent acid-catalyzed acetal formation that allows efficient and fast construction of functionalized dioxabicyclo- and oxaazabicyclo[3.3.1]nonane structures that are important motifs in several natural products and pharmaceutically interesting compounds.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.