The Pd-catalysed direct arylation of heteroarene CH bonds by 2- or 4-bromobenzamides has been achieved. In the presence of KOAc as the base, no CN bond formation or CC coupling of two bromobenzamides was observed. Both primary and tertiary amides can be employed for CC cross-coupling of 4-bromobenzamides with a variety of heteroarenes to give the C5-arylated heteroarenes in good yields by using a low loading (0.5 mol %) of Pd(OAc)2 catalyst. However, no coupling product was observed with 2-bromobenzamide, and a moderate reactivity of 2-bromo-N,N-diethylbenzamide has been observed with 2 mol % PdCl(C3H5)(dppb) (dppb=1,4-bis(diphenylphosphino)butane) as the catalyst. A moderate influence due to the nature of the heteroarene was observed, and thiazoles, thiophenes, furans and pyrroles have been arylated successfully. The reaction of a thiazole with 2-bromo-N-phenylbenzamide led to a six-membered ring product by intramolecular cyclisation, whereas a 2-bromo-N-benzylbenzamide gave the desired intermolecular coupling product.