Chiral Cyclopentadienyl-type Ligands: a New Breakthrough for Asymmetric C[BOND]H Functionalisation

Authors

  • Dr. Jean-Baptiste Sortais,

    Corresponding author
    1. UMR 6226 CNRS-Université de Rennes 1, Institut des “Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre of Catalysis and Green Chemistry, Campus de Beaulieu, Ave Général Leclerc 35042—Rennes (France), Fax: (+33) 2-23-23-69-39
    • UMR 6226 CNRS-Université de Rennes 1, Institut des “Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre of Catalysis and Green Chemistry, Campus de Beaulieu, Ave Général Leclerc 35042—Rennes (France), Fax: (+33) 2-23-23-69-39
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  • Prof. Dr. Christophe Darcel

    Corresponding author
    1. UMR 6226 CNRS-Université de Rennes 1, Institut des “Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre of Catalysis and Green Chemistry, Campus de Beaulieu, Ave Général Leclerc 35042—Rennes (France), Fax: (+33) 2-23-23-69-39
    • UMR 6226 CNRS-Université de Rennes 1, Institut des “Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre of Catalysis and Green Chemistry, Campus de Beaulieu, Ave Général Leclerc 35042—Rennes (France), Fax: (+33) 2-23-23-69-39
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Abstract

original image

Ligand breakthrough: Using a well-designed chiral cyclopentadienyl rhodium complex as the catalyst, an efficient asymmetric C[BOND]H bond functionalization/cyclization was performed at RT in the presence of a catalytic amount of dibenzoylperoxide (DBPO) leading to tetrahydroiso-quinolinone derivatives with moderate to good yields and very good enantiomeric ratios.

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