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Three Carbons for Complexity! Recent Developments of Palladium-Catalyzed Reactions of Allenes

Authors

  • Dr. Tilman Lechel,

    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany), Fax: (+49) 30-8385-5367
    2. LGC Ltd, Im Biotechnologiepark TGZ II, 14943 Luckenwalde (Germany)
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  • Dr. Fabian Pfrengle,

    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany), Fax: (+49) 30-8385-5367
    2. Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037 La Jolla (USA)
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  • Prof. Dr. Hans-Ulrich Reissig,

    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany), Fax: (+49) 30-8385-5367
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  • Dr. Reinhold Zimmer

    Corresponding author
    1. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany), Fax: (+49) 30-8385-5367
    • Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany), Fax: (+49) 30-8385-5367
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Abstract

The three carbon atoms of allene moieties allow unique transformations and rapid generation of complexity. Not surprisingly, allenes became extremely versatile building blocks in organic synthesis. Transition-metal-catalyzed reactions of these cumulene π-systems have been particularly successful, and many applications in the synthesis of complex products have been reported. This review summarizes the palladium-catalyzed transformation of allenes published during the last decade. Many of the examples presented are impressive multicomponent processes or cascade reactions involving two or more steps leading to molecular complexity in simple one-pot operations. Consequently, several reactions have been developed with the goal of delivering new synthetic routes to natural products.

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