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Keywords:

  • amination;
  • carbonyl compounds;
  • heterocycle synthesis;
  • hydrogenation;
  • metal–organic frameworks

Abstract

Bifunctional MIL-101 MOFs containing Lewis acid Cr3+ sites and Pd or Pt hydrogenation/reduction centers, either as isolated metal complexes or in the form of encapsulated metal nanoparticles, have shown to be highly active catalysts for the one-pot nitroarene reduction and reductive amination of carbonyl compounds. This preparation procedure has been successfully applied to the synthesis of secondary arylamines, quinolines, pyrrols, and 3-arylpyrrolidines. In all the cases, the MOFs have shown superior performances with respect to commercially available Pd and Pt metal catalysts under the same conditions.