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Keywords:

  • amino acids;
  • biocatalysis;
  • enantioselectivity;
  • enzymes;
  • Michael addition
Thumbnail image of graphical abstract

Unnatural reactions: We report the synthesis of a large variety of N-substituted aspartic acids by addition of structurally diverse amines to fumaric acid; the reactions are catalyzed by a previously engineered variant of methylaspartate ammonia lyase. The additions are highly enantioselective and yield only the L enantiomers of the corresponding amino acid products (>99 % ee).