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Keywords:

  • 1,4-addition;
  • allylic substitution;
  • asymmetric catalysis;
  • boron;
  • hydrometalation
Thumbnail image of graphical abstract

From pots and pans to hydrometalation: Hydrometalation reactions using boron and zirconium hydrides transform alkenes into useful alkylmetal nucleophiles. These nucleophiles can be employed in the copper-catalyzed 1,4-additions to α,β-unsaturated carbonyl compounds or allylic substitutions. Important advances have been achieved recently, which enabled also enantioselective versions of these transformations.