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Asymmetric Copper-catalyzed 1,4-Additions and Allylic Substitutions with Nucleophiles Formed by the Hydrometalation of Alkenes

Authors

  • Dr. Radovan Šebesta

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    1. Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, SK-84215 Bratislava (Slovakia), Fax: (+421) 2-60296337
    • Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina CH2, SK-84215 Bratislava (Slovakia), Fax: (+421) 2-60296337
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Abstract

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From pots and pans to hydrometalation: Hydrometalation reactions using boron and zirconium hydrides transform alkenes into useful alkylmetal nucleophiles. These nucleophiles can be employed in the copper-catalyzed 1,4-additions to α,β-unsaturated carbonyl compounds or allylic substitutions. Important advances have been achieved recently, which enabled also enantioselective versions of these transformations.

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