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Keywords:

  • aryl boronic acids;
  • C[BOND]H activation;
  • indole;
  • metal–organic frameworks;
  • Pd nanoparticles

Abstract

Highly dispersed Pd nanoparticles encapsulated in the mesoporous metal–organic framework MIL-101 demonstrated high activity and selectivity for the direct C2 arylation of various indoles with aryl boronic acids using O2 or 2,2,6,6-tetramethylpiperidine N-oxyradical as an external oxidant in acidic media under mild conditions. The green catalyst is easily recoverable and can be reused six times without leaching and loss of activity.