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Direct C[BOND]H Bond Arylation of Indoles with Aryl Boronic Acids Catalyzed by Palladium Nanoparticles Encapsulated in Mesoporous Metal–Organic Framework

Authors

  • Dr. Yuanbiao Huang,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710
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  • Tao Ma,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710
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  • Dr. Ping Huang,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710
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  • Dongshuang Wu,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710
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  • Dr. Zujin Lin,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710
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  • Prof. Rong Cao

    Corresponding author
    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710
    • State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155, Yangqiao Road West, Fuzhou 350002 (People's Republic of China), Fax: (+86) 591-83796710

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Abstract

Highly dispersed Pd nanoparticles encapsulated in the mesoporous metal–organic framework MIL-101 demonstrated high activity and selectivity for the direct C2 arylation of various indoles with aryl boronic acids using O2 or 2,2,6,6-tetramethylpiperidine N-oxyradical as an external oxidant in acidic media under mild conditions. The green catalyst is easily recoverable and can be reused six times without leaching and loss of activity.

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