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Keywords:

  • alkylation;
  • asymmetric catalysis;
  • C[BOND]H activation;
  • β-ketoesters;
  • palladium
Thumbnail image of graphical abstract

Put your Trost in this reaction: The first catalytic asymmetric Tsuji–Trost reaction via allylic C[BOND]H activation was realized using a new class of chiral phosphoramidite ligands. This work represents a considerable breakthrough in palladium catalyzed asymmetric allylic C[BOND]H alkylations.