Get access

Asymmetric Allylic Alkylation of Alkene through Direct C (sp3)-H Functionalization

Authors

  • Dr. Guihua Chen,

    1. Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871 (P.R. China)
    Search for more papers by this author
  • Kang Chen,

    1. Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871 (P.R. China)
    Search for more papers by this author
  • Prof. Zhang-Jie Shi

    Corresponding author
    1. Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871 (P.R. China)
    2. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 (P.R. China)
    • Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871 (P.R. China)
    Search for more papers by this author

Abstract

original image

Put your Trost in this reaction: The first catalytic asymmetric Tsuji–Trost reaction via allylic C[BOND]H activation was realized using a new class of chiral phosphoramidite ligands. This work represents a considerable breakthrough in palladium catalyzed asymmetric allylic C[BOND]H alkylations.

Get access to the full text of this article

Ancillary