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Asymmetric Biocatalytic Cannizzaro-Type Reaction

Authors

  • Christiane Wuensch,

    1. Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
    2. ACIB GmbH c/o, Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria)
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    • These authors contributed equally to this work.

  • Horst Lechner,

    1. Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
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    • These authors contributed equally to this work.

  • Dr. Silvia M. Glueck,

    1. Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
    2. ACIB GmbH c/o, Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria)
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  • Prof. Dr. Klaus Zangger,

    1. Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
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  • Dr. Mélanie Hall,

    Corresponding author
    1. Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
    • Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840

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  • Prof. Dr. Kurt Faber

    Corresponding author
    1. Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
    • Department of Chemistry, University of Graz, Heinrichstraße 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840

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Abstract

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Blowing out of disproportion: Alcohol dehydrogenases were found to catalyze a bio-Cannizzaro-type reaction. The disproportionation of various aldehydes into their corresponding alcohols and carboxylic acids was achieved in a redox-neutral process. The asymmetric variant proceeded with high stereoselectivities.

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