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One-Pot Production of Enantiopure Alkylamines and Arylalkylamines of Opposite Chirality Catalyzed by ω-Transaminase

Authors

  • Eul-Soo Park,

    1. Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul (South Korea), Fax: (+82) 2-362-7265
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    • These authors contributed equally to this work.

  • Dr.  M. Shaheer Malik,

    1. Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul (South Korea), Fax: (+82) 2-362-7265
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    • These authors contributed equally to this work.

  • Joo-Young Dong,

    1. Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul (South Korea), Fax: (+82) 2-362-7265
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  • Prof. Dr. Jong-Shik Shin

    Corresponding author
    1. Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul (South Korea), Fax: (+82) 2-362-7265
    • Department of Biotechnology, Yonsei University, 262 Seongsanno, Seodaemun-Gu, 120-749 Seoul (South Korea), Fax: (+82) 2-362-7265

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Abstract

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Looking for favors: The thermodynamically favorable asymmetric amination of alkyl ketones was catalyzed by ω-transaminase with racemic arylalkylamines as an amine donor, thus affording enantiopure alkylamines and arylalkylamines of opposite chirality.

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