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Synthesis of 2,5-Diarylpyrroles by Ligand-Free Palladium-Catalyzed CH Activation of Pyrroles in Ionic Liquids

Authors

  • Peter Ehlers,

    1. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059 Rostock (Germany)
    2. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
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  • Andranik Petrosyan,

    1. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059 Rostock (Germany)
    2. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
    3. Faculty of Chemistry, Yerevan State University, Alex Manoogian 1, 0025 Yerevan (Armenia)
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  • Jens Baumgard,

    1. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059 Rostock (Germany)
    2. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
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  • Stefan Jopp,

    1. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059 Rostock (Germany)
    2. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
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  • Dr. Norbert Steinfeld,

    1. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
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  • Prof. Dr. Tariel V. Ghochikyan,

    1. Faculty of Chemistry, Yerevan State University, Alex Manoogian 1, 0025 Yerevan (Armenia)
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  • Prof. Dr. Ashot S. Saghyan,

    1. Faculty of Chemistry, Yerevan State University, Alex Manoogian 1, 0025 Yerevan (Armenia)
    2. Scientific and Production Center “Armbiotechnology” of NAS RA, Gyurjyan str. 14, 0056 Yerevan (Armenia)
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  • Dr. Christine Fischer,

    1. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
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  • Prof. Dr. Peter Langer

    Corresponding author
    1. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059 Rostock (Germany)
    2. Leibniz-Institut für Katalyse an der Universität Rostock e.V. Albert Einstein Str. 29a, 18059 Rostock (Germany)
    • Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, 18059 Rostock (Germany)
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Abstract

The palladium-catalyzed CH activation and arylation of N-methylpyrrole and N-phenylpyrrole allowed a convenient synthesis of diarylpyrroles. The reactions were performed by using tetrabutylammonium acetate as an ionic solvent, which allowed for the application of a ligand-free catalytic system by using simple palladium salts or polyvinylpyrrolidone-stabilized palladium nanoparticles as the catalyst.

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