Get access

Tandem Synthesis of N-Alkylated Amides from Aldoximes and Alcohols by Using a Ru/Ir Dual-Catalyst System

Authors

  • Dr. Feng Li,

    Corresponding author
    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P. R. China), Fax: (+86) 25-84431939
    • School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P. R. China), Fax: (+86) 25-84431939
    Search for more papers by this author
  • Panpan Qu,

    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P. R. China), Fax: (+86) 25-84431939
    Search for more papers by this author
  • Juan Ma,

    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P. R. China), Fax: (+86) 25-84431939
    Search for more papers by this author
  • Xiaoyuan Zou,

    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P. R. China), Fax: (+86) 25-84431939
    Search for more papers by this author
  • Chunlou Sun

    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P. R. China), Fax: (+86) 25-84431939
    Search for more papers by this author

Abstract

original image

In the same boat: Tandem rearrangement/N-alkylation reactions in the presence of a Ru/Ir dual-catalyst system affords the desired N-alkylated amines in good-to-excellent yields with no intermediate amides or over-alkylated N,N-dialkylated amides. This environmentally friendly tandem reaction employs readily available starting materials, affords excellent selectivities for the N-alkylated amides, and shows high atom efficiency.

Ancillary