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Keywords:

  • asymmetric catalysis;
  • hydrogenation;
  • ligand design;
  • iridium;
  • N,P-ligands

Abstract

We have replaced the oxazoline group with a thiazoline moiety in one of the most successful of the phosphite–oxazoline ligand families for the Ir-catalyzed hydrogenation of minimally functionalized olefins. A small but structurally important library of Ir phosphite–thiazoline precatalysts (Ir-L1L2ae) has been developed by changing the substituents/configurations at the biaryl phosphite group. We found that the replacement of the oxazoline with a thiazoline moiety in the ligand design is beneficial in terms of substrate scope.