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Expanded Scope of the Asymmetric Hydrogenation of Minimally Functionalized Olefins Catalyzed by Iridium Complexes with Phosphite–Thiazoline Ligands

Authors

  • Dr. Javier Mazuela,

    1. Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel⋅li Domingo s/n. 43007 Tarragona (Spain), Fax: 34-977559563, Tel: 34-977558780
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  • Dr. Oscar Pàmies,

    Corresponding author
    1. Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel⋅li Domingo s/n. 43007 Tarragona (Spain), Fax: 34-977559563, Tel: 34-977558780
    • Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel⋅li Domingo s/n. 43007 Tarragona (Spain), Fax: 34-977559563, Tel: 34-977558780
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  • Prof. Montserrat Diéguez

    Corresponding author
    1. Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel⋅li Domingo s/n. 43007 Tarragona (Spain), Fax: 34-977559563, Tel: 34-977558780
    • Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel⋅li Domingo s/n. 43007 Tarragona (Spain), Fax: 34-977559563, Tel: 34-977558780
    Search for more papers by this author

Abstract

We have replaced the oxazoline group with a thiazoline moiety in one of the most successful of the phosphite–oxazoline ligand families for the Ir-catalyzed hydrogenation of minimally functionalized olefins. A small but structurally important library of Ir phosphite–thiazoline precatalysts (Ir-L1L2ae) has been developed by changing the substituents/configurations at the biaryl phosphite group. We found that the replacement of the oxazoline with a thiazoline moiety in the ligand design is beneficial in terms of substrate scope.

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