Powerful Amino Acid Derived Bifunctional Phosphine Catalysts Bearing a Hydrogen Bond Donor in Asymmetric Synthesis

Authors

  • Prof. Dr. Li-Wen Xu

    Corresponding author
    1. Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou (P. R. China), Fax: (+86) 531-28865135
    2. School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P. R. China)
    • Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou (P. R. China), Fax: (+86) 531-28865135
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Abstract

This minireview focuses on the recent advances in the synthetic application of amino acid-derived bifunctional phosphine catalysts bearing a hydrogen-bond donor. In the examples illustrated, the amino acid-based phosphines have already been proven to be versatile, catalyzing a wide range of asymmetric reactions, including (aza)-MBH reactions, [3+2] cyclizations, [4+2] cycloadditions, allylic alkylation, and Michael addition.

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