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Nickel-Catalysed Reductive Amination with Hydrosilanes

Authors

  • Jianxia Zheng,

    1. UMR 6226 CNRS-UR1 “Institut des Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre for Catalysis and Green Chemistry, Université Rennes 1, 263 av. du Général Leclerc, 35046 Rennes Cedex (France), Fax: (+33) 2 23 23 69 39
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  • Dr. Thierry Roisnel,

    1. UMR 6226 CNRS-UR1 “Institut des Sciences Chimiques de Rennes”, Centre de Diffractométrie X, Université Rennes 1, 263 av. du Général Leclerc, 35046 Rennes Cedex (France)
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  • Prof. Dr. Christophe Darcel,

    Corresponding author
    1. UMR 6226 CNRS-UR1 “Institut des Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre for Catalysis and Green Chemistry, Université Rennes 1, 263 av. du Général Leclerc, 35046 Rennes Cedex (France), Fax: (+33) 2 23 23 69 39
    • UMR 6226 CNRS-UR1 “Institut des Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre for Catalysis and Green Chemistry, Université Rennes 1, 263 av. du Général Leclerc, 35046 Rennes Cedex (France), Fax: (+33) 2 23 23 69 39
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  • Dr. Jean-Baptiste Sortais

    Corresponding author
    1. UMR 6226 CNRS-UR1 “Institut des Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre for Catalysis and Green Chemistry, Université Rennes 1, 263 av. du Général Leclerc, 35046 Rennes Cedex (France), Fax: (+33) 2 23 23 69 39
    • UMR 6226 CNRS-UR1 “Institut des Sciences Chimiques de Rennes”, Team “Organometallics: Materials and Catalysis”, Centre for Catalysis and Green Chemistry, Université Rennes 1, 263 av. du Général Leclerc, 35046 Rennes Cedex (France), Fax: (+33) 2 23 23 69 39
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Abstract

original image

That's just silyl! Selective nickel-catalyzed reductive amination of aldehydes under hydrosilylation conditions is achieved by using a one pot, two step procedure. By using an in situ-generated catalyst (5 mol %) from Ni(OAc)2 and tricyclohexylphosphine with tetramethyldisiloxane (TMDS) as the hydrosilane at 70 °C, the corresponding secondary amines were obtained in moderate to good isolated yields.

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