Get access

Simple Organic Molecules as Catalysts for the Enantioselective Synthesis of Amines and Alcohols

Authors

  • Dr. Yi Cui,

    1. Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 03-5684-0634
    Search for more papers by this author
  • Prof. Dr. Shū Kobayashi

    Corresponding author
    1. Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 03-5684-0634
    • Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 03-5684-0634
    Search for more papers by this author

Abstract

original image

Valiant catalysis: Hoveyda et al. have developed a set of catalysts derived from valine for enantioselective syntheses. Reagents are inexpensive, allyl additions are scalable, harsh conditions are avoided, and reactions can be performed with 0.25 mol % catalyst in under 6 h at room temperature. The efficiency, economy, selectivity, and simplicity of the transformations and the range of boron reagents look to have sustained impact on future progress in amine and alcohol syntheses.

Get access to the full text of this article

Ancillary