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Keywords:

  • aldol reaction;
  • alkynes;
  • aldehydes;
  • asymmetric synthesis;
  • organocatalysis

Abstract

The direct cross-aldol reaction of alkynyl aldehydes catalyzed by a trifluoromethylated diarylprolinol provides a practical route for the highly enantioselective synthesis of chiral β-alkynyl-β-hydroxy aldehydes. Good anti selectivity and excellent enantioselectivity were obtained in the reactions of silylpropynals, which afford synthetically useful chiral building blocks.