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Keywords:

  • biaryls;
  • C[BOND]H activation;
  • diaryliodonium salts;
  • palladium;
  • water chemistry
Thumbnail image of graphical abstract

Get down with the func(tionalization): An efficient and practical protocol for the C[BOND]H ortho arylation of benzoic acids with diaryliodonium salts by using water as an environmentally benign, nontoxic reaction medium is developed. The choice of water as the solvent is crucial for this reaction, which sets the stage for the broad application of aqueous conditions in C[BOND]H functionalization reactions.