Palladium-Catalyzed C[BOND]H ortho Arylation of Benzoic Acids with Diaryliodonium Salts in Water

Authors

  • Zhiqing Wu,

    1. Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
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  • Si Chen,

    1. Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
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  • Chenxu Hu,

    1. Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
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  • Dr. Zhengkai Li,

    1. Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
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  • Dr. Haifeng Xiang,

    1. Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
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  • Prof. Dr. Xiangge Zhou

    Corresponding author
    1. Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
    2. Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123 (P.R. China)
    • Institute of Homogeneous Catalysis, College of Chemistry, Sichuan University, Chengdu 610064 (P.R. China), Fax: (+86) 28-8541-2026
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Abstract

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Get down with the func(tionalization): An efficient and practical protocol for the C[BOND]H ortho arylation of benzoic acids with diaryliodonium salts by using water as an environmentally benign, nontoxic reaction medium is developed. The choice of water as the solvent is crucial for this reaction, which sets the stage for the broad application of aqueous conditions in C[BOND]H functionalization reactions.

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