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Keywords:

  • amines;
  • asymmetric synthesis;
  • biocatalysis;
  • imine reductase;
  • Streptomyces
Thumbnail image of graphical abstract

Biocatalytic imine reduction: A whole-cell recombinant E. coli system, producing an (S)-selective imine reductase (IRED) from Streptomyces sp. GF3546, is developed. This biocatalyst is used for the enantioselective reduction of a broad range of substrates such as dihydroisoquinolines and dihydro-β-carbolines as well as iminium ions.