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Asymmetric Reduction of Cyclic Imines Catalyzed by a Whole-Cell Biocatalyst Containing an (S)-Imine Reductase

Authors

  • Dr. Friedemann Leipold,

    1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN (UK), Fax: (+44) 161-445-0093
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  • Shahed Hussain,

    1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN (UK), Fax: (+44) 161-445-0093
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  • Diego Ghislieri,

    1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN (UK), Fax: (+44) 161-445-0093
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  • Prof. Nicholas J. Turner

    Corresponding author
    1. School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN (UK), Fax: (+44) 161-445-0093
    • School of Chemistry, University of Manchester, Manchester Institute of Biotechnology, 131 Princess Street, Manchester, M1 7DN (UK), Fax: (+44) 161-445-0093

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Abstract

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Biocatalytic imine reduction: A whole-cell recombinant E. coli system, producing an (S)-selective imine reductase (IRED) from Streptomyces sp. GF3546, is developed. This biocatalyst is used for the enantioselective reduction of a broad range of substrates such as dihydroisoquinolines and dihydro-β-carbolines as well as iminium ions.

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