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Copper(I)-Catalyzed Wittig Olefination Reactions of N-Tosylhydrazones with Trifluoromethylketones

Authors

  • Dr. Qiang Sha,

    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P.R. of China), Fax: (+86) 25-84317078
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  • Prof. Yunyang Wei

    Corresponding author
    1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P.R. of China), Fax: (+86) 25-84317078
    • School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094 (P.R. of China), Fax: (+86) 25-84317078

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Abstract

Cuprous iodide-catalyzed Wittig olefination reactions of N-tosylhydrazones with trifluoromethylketones are reported. This procedure provides an efficient method for the synthesis of various trifluoromethyl-substituted alkenes in moderate to good yields (up to 89 % yield) and good stereoselectivity (up to 93 % E-selectivity). To the best of our knowledge, it is the first report of a Wittig reaction of N-tosylhydrazones with ketones.

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