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Keywords:

  • artificial pathway;
  • biocatalysis;
  • domino reactions;
  • redox chemistry;
  • retrosynthesis
Thumbnail image of graphical abstract

Joined forces: Alcohol dehydrogenase, enoate reductase, and Baeyer–Villiger monooxygenase are combined in a cascade reaction by coexpression in E. coli to have a recombinant whole-cell biocatalyst. Such an artificial metabolic “mini”-pathway provides access to functionalized chiral compounds in high yields and optical purities as exemplified for kinetic resolutions, desymmetrizations, and regiodivergent biotransformations.