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Keywords:

  • chemoselectivity;
  • heterogeneous catalysis;
  • hydrogenation;
  • palladium;
  • solvent effects

Abstract

We have developed a highly chemoselective hydrogenation method using a novel palladium catalyst supported on spherical carbon (0.5 % Pd/SC). The 0.5 % Pd/SC exhibited a novel catalytic activity and could achieve the chemoselective hydrogenation of alkynes, alkenes, azides, nitro groups, and aliphatic O-tert-butyldimethylsilyl (TBS) ethers without hydrogenolysis of benzyl esters, benzyl ethers, nitriles, aromatic ketones, N-carbobenzyloxy (N-Cbz) protective groups, and aromatic O-TBS ethers.