Chemoselective Hydrogenation Catalyzed by Pd on Spherical Carbon

Authors

  • Dr. Hiroyoshi Esaki,

    Corresponding author
    1. Department of Chemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan), Fax: (+81) 798-45-6435
    • Hiroyoshi Esaki, Department of Chemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan), Fax: (+81) 798-45-6435

      Hironao Sajiki, Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109

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  • Tomohiro Hattori,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109
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  • Aya Tsubone,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109
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  • Satoko Mibayashi,

    1. Department of Chemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan), Fax: (+81) 798-45-6435
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  • Dr. Takao Sakata,

    1. Research Centre for Ultra-High Voltage Electron Microscopy, Osaka University, 7-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan)
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  • Dr. Yoshinari Sawama,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109
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  • Dr. Yasunari Monguchi,

    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109
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  • Prof. Dr. Hidehiro Yasuda,

    1. Research Centre for Ultra-High Voltage Electron Microscopy, Osaka University, 7-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan)
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  • Prof. Dr. Kazuto Nosaka,

    1. Department of Chemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan), Fax: (+81) 798-45-6435
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  • Prof. Dr. Hironao Sajiki

    Corresponding author
    1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109
    • Hiroyoshi Esaki, Department of Chemistry, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501 (Japan), Fax: (+81) 798-45-6435

      Hironao Sajiki, Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 21-25-4 Daigaku-nishi, Gifu 501-1196 (Japan), Fax: (+81) 58-230-8109

    Search for more papers by this author

Abstract

We have developed a highly chemoselective hydrogenation method using a novel palladium catalyst supported on spherical carbon (0.5 % Pd/SC). The 0.5 % Pd/SC exhibited a novel catalytic activity and could achieve the chemoselective hydrogenation of alkynes, alkenes, azides, nitro groups, and aliphatic O-tert-butyldimethylsilyl (TBS) ethers without hydrogenolysis of benzyl esters, benzyl ethers, nitriles, aromatic ketones, N-carbobenzyloxy (N-Cbz) protective groups, and aromatic O-TBS ethers.

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