New Site-Selective Organoradical Based on Hypervalent Iodine Reagent for Controlled Alkane sp3 C[BOND]H Oxidations

Authors

  • Dr. Toshifumi Dohi,

    1. Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1Nojihigashi, Kusatsu, Shiga 525-8577 (Japan), Fax:(+81) 77-561-5829
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  • Prof. Dr. Yasuyuki Kita

    Corresponding author
    1. Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1Nojihigashi, Kusatsu, Shiga 525-8577 (Japan), Fax:(+81) 77-561-5829
    • Ritsumeikan University, College of Pharmaceutical Sciences, 1-1-1Nojihigashi, Kusatsu, Shiga 525-8577 (Japan), Fax:(+81) 77-561-5829

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Abstract

original image

Large Iodine: The site-selective oxidation of unactivated secondary sp3 C[BOND]H bonds was accomplished by using a newly defined reactive hypervalent iodine(III) radical in the presence of tert-butyl hydroperoxide (see scheme). Recent studies on hypervalent iodine radicals have significantly contributed to the further development and design of organic molecules in radical oxidation chemistry.

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